ANICT

Towards a sustainable research career with progression based on merit

ANICT MSc Fellowship: Searching for biocompatible dental reconstruction

Conceição Montenegro, member of ANICT and researcher at  Universidade do Porto, was the winner in the “Health Sciences” field of the 2012 ANICT Msc Fellowships awards. She will supervise the MSc candidate Tiago Sousa, to pursue his thesis in Pharmaceutical Sciences at the University of Porto, in the theme of “ Evaluation of the release  methyl methacrylate monomers in dental restorative materials: use of HPLC coupled with efficient sample extraction processes”.

ANICT member Conceição Montenegro (left) and MSc candidate Tiago Sousa (right)

More about the MSc project:

The most used polymer for denture bases fabrication is polymethyl methacrylate (PMMA), obtained by mixture of this polymer powder with liquid monomer methyl methacrylate (MMA). The polymerization reaction may occur through different methods: heat-polymerization, auto-polymerization, microwave and visible light polymerization. The  conversion of monomers into polymers is never complete and the unreacted MMA monomers remain in the denture base in the range of 0,1 to 5% (w/w) . The ISO 1567 standard specifies that the maximum residual monomer content should not exceed 2,2% (w/w), arguing potential cito and/or genotoxic effects.  The project aims to develop and validate an analytical method for the determination of MMA in saliva samples subjected to direct contact with PMMA resins obtained through different polymerization methods to establish a correlation between the polymerization process and the amount of toxic .monomers. The method it will be based on HPLC – UV detection associated with analyte extraction by dispersive liquid- liquid microextraction technique. In the future, this  study will give an indication on which of the processes is safer under the clinical point of view, after studies of cito/genotoxic effects in living cells.

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One response to “ANICT MSc Fellowship: Searching for biocompatible dental reconstruction

  1. zahnarzt berlin July 11, 2012 at 7:53 am

    the knowledge about the specification of polymers is hardly mentioned. the text mention is quite useful and helpful for new dental student and for those who have teeth problems.

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